Bcl2l11^tm2Rjd

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Species

Mus musculus

Symbol

Bcl2l11^tm2Rjd

Category

allele

Allele of gene

Bcl2l11

Transgenic Constructs

None

Synonyms

• Bim^3SA

Description

A floxed neo cassette was inserted within intron 4, and specific mutations in exon 3 were introduced by homologous recombination. Mutations resuted in three sites of MAPK phosphorylation (Ser-55, Ser-65, and Ser-73) in exon 3 to be substituted with alanines (S55A, S65A, S73A). The neo cassette was then excised with cre recombinase leaving a single loxP site in intron 4. Expression of normal amounts of mutant proteins was confirmed by immunoblot.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations