Allele/Variant

Card11m1Btlr

Species
Mus musculus
Symbol
Card11m1Btlr
Category
allele
Allele of gene
Card11
Transgenic Constructs
None
Synonyms
  • king
Description
This mutation was identified in a screen of G3 progeny of an ENU-mutagenized male mouse for developmental and/or functional CD8+ T cell abnormalities. It comprises an A-to-T transversion at nucleotide position 1791 of the gene (Genbank Accession NM_175362.1) that is predicted to result in replacement of leucine by glutamine at amino acid position 525 of the 1159-amino acid protein (L525Q). Western blot analysis detects no CARD11 protein from the mutant allele in the spleen or lymph nodes, and thymic expression is reduced.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations