Allele/Variant

Grm7tm1Betz

Species
Mus musculus
Symbol
Grm7tm1Betz
Category
allele
Allele of gene
Grm7
Transgenic Constructs
None
Synonyms
  • mGluR7aAAA
Description
The last three codons in exon 10 comprising the C-terminal PDZ-ligand motif were replaced with alanine codons via homologous recombination. A floxed neo cassette was also inserted and subsequently removed by Cre mediated recombination in the ES cells. Western blot analysis indicated that protein levels were reduced by about 35% and 15% in the brains of homozygous and heterozygous mice, respectively.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations