Apobec3^Rfv3-r

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Species

Mus musculus

Symbol

Apobec3^Rfv3-r

Category

allele

Allele of gene

Apobec3

Transgenic Constructs

None

Synonyms

None

Description

This gene locus controls recovery from viremia and leukemia induced by Friend virus (FV). This dominant allele is found in C57BL/6J, C57BL/10, and 129P2/OlaHsd strains and allows for recovery from both viremia and leukemia in H2^b mice. Recovery from viremia only is seen in H2^a mice. This allele produces a full length mRNA transcript (including exon 2) that encodes for a protein with potent anti-viral activity.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations