Apobec3^Rfv3-s

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Species

Mus musculus

Symbol

Apobec3^Rfv3-s

Category

allele

Allele of gene

Apobec3

Transgenic Constructs

None

Synonyms

None

Description

This gene locus controls recovery from viremia and leukemia induced by Friend virus (FV). This recessive allele is found in BALB/c, and A.BY strains and is associated with high FV titers after inoculation. This allele produces an alternative mRNA transcript that excludes exon 2 and produces a protein that is 3- to 5- fold less potent in anti-viral activity as the protein encoded by the Apobec3^Rfv3-s allele.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations