Allele/Variant

Tlr7rsq2

Species
Mus musculus
Symbol
Tlr7rsq2
Category
allele
Allele of gene
Tlr7
Transgenic Constructs
None
Synonyms
None
Description
This mutation was discovered in a toll-like receptor (TLR) signaling screen of the G3 progeny of an ENU mutagenized male mouse. It has been identified as an A to T transversion at nucleotide position 732 (Genbank: NM_133211), in the third and final exon, that results in the replacement of a highly conserved asparagine by tyrosine at amino acid position 182 of the protein (N182Y), in the fifth leucine rich repeat (LRR) of the receptor's ectodomain.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal macrophage physiology
MGI
decreased tumor necrosis factor secretion
MGI
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Disease Associations

No data available