Itsn1^tm2.1Mapr

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Species

Mus musculus

Symbol

Itsn1^tm2.1Mapr

Category

allele

Allele of gene

Itsn1

Transgenic Constructs

None

Synonyms

• Itsn1-LK^-

Description

A neo cassette with a 5' loxP site was inserted upstream of exon 32 and an additional loxP site was inserted downstream of exon 32. Transient cre expression in ES cells was used to removed the neo cassette and exon 32 causing a frame shift and premature termination of translation. The absence of the long form of the protein was confirmed by western blot analysis on brain and heart extracts.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations