Tg(tetO-TGFB1*C223S*C225S)1Glk

---

Species

Mus musculus

Symbol

Tg(tetO-TGFB1*C223S*C225S)1Glk

Category

allele

Allele of gene

None

Transgenic Constructs

None

Synonyms

• tetOTGFB1

Description

The porcine TGFbeta1 (TGFB1) cDNA containing a double mutation where cysteines at positions 223 and 225 converted to serines is driven by a heptameric tetO sequence and a CMV minimal promoter. The construct also contains a beta-globin intron. Founders were identified by Southern blotting. Mice express the porcine TGFB1 constitutively as a result of the two mutations. TGFB1 expression can be suppressed by crossing this line with a line expressing the tTA transactivator and maintaining pregnant females on a doxycycline-containing water supply.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations