Allele/Variant

Tg(CAG-cat,-Ptpn11*Q97R)1Rbns

Species

Mus musculus

Category

allele

Allele of gene

None

Transgenic Constructs

Synonyms

CAGCAT-Q79R-Shp2

Description

The ubiquitous CAG (chicken beta actin) promoter was used to drive cre-dependent expression of a modified Ptpn11 gene, which contains the amino acid substitution of arginine for glutamine at position 79, following removal of an intervening floxed chloramphenicol (cat) gene. The amino acid substitution results in an increase in phosphatase activity. Three lines were created and line 1 was used in subsequent experiments.

Additional Information

Literature

Transgenic Constructs

This allele contains 1 transgenic construct

Symbol

Expressed Components

Ptpn11

Knock-down Targets

None

Regulatory Regions

None

All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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Disease Associations

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