Allele/Variant

Ccr10/Cntnap1tm1Bhat

Species
Mus musculus
Symbol
Ccr10/Cntnap1tm1Bhat
Category
allele
Allele of gene
Ccr10
Transgenic Constructs
None
Synonyms
  • Caspr-
  • Cntnap1tm1Bhat
Description
A targeting vector disrupted two genes via homologous recombination. Regulatory sequences and the first 7 exons of the Cntnap1 gene were replaced with a neomycin resistance cassette, as were the first two coding exons of the Ccr10 gene. Loss of Cntnap1 gene expression in homozygous mutants was demonstrated by Western blot analysis of whole brain and sciatic nerve homogenates and by immunohistochemistry of sciatic nerves and CNS. Effects on Ccr10 gene expression were not examined though the mutation was predicted to be a null allele due to the removal of the transcription start site for the gene.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

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    Disease Associations

    Association
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