Il17f^tm1Yiw

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Species

Mus musculus

Symbol

Il17f^tm1Yiw

Category

allele

Allele of gene

Il17f

Transgenic Constructs

None

Synonyms

• IL-17F

Description

This gene locus lies within 60 kb of the highly homologous gene locus Il17A. In order to generate a double mutant, ES cells heterozygote for the Il17a^tm1Yiw null allele were retargeted with a second vector to the Il17f locus. A hygromycin resistance gene replaced exons 2 and 3 of the allele that was in trans with the Il17a^tm1Yiw allele. The two mutant loci were bred apart and gene inactivation of just the Il17f allele was confirmed by RT-PCR of activated splenocytes collected from homozygote mice.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations