Version: 8.0.0
Date: Tue Jan 28 2025
Tg(Prnp-ATN1)150Dbo
MGI:3831358Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Tg(Prnp-ATN1)150Dbo

Species
Mus musculus
Symbol
Tg(Prnp-ATN1)150Dbo
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • AT-FL-65Q-150
Description
The transgene comprises a cDNA encoding full length human atrophin 1 containing a 65 residue polyglutamine tract, encoded by 65 CAG repeats, inserted into an expression cassette containing the promoter, 5' intronic and 5' and 3' untranslated region sequences of the mouse prion protein gene. This transgenic line carries more than ten copies of the construct and, as shown by northern and western blot analysis, expresses human atrophin 1 mRNA and protein in the brain.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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