Allele/Variant

Tg(Thy1-SERPINI1*G392E)333Icka

Species
Mus musculus
Symbol
Tg(Thy1-SERPINI1*G392E)333Icka
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • G392E-Tg
Description
The promoter was used to drive neuron-specific expression of the human cDNA containing nucleotide substitutions that result in the amino acid substitution of glutamic acid for glycine at position 392 (G392E). This mutation was originally discovered in patients with familial encephalopathy with neuroserpin inclusion bodies (FENIB). Three lines were created (333, 42, 115) with line 333 expressing at much higher levels than lines 42 and 115.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations