Allele/Variant

Tg(Plp1-Ncre)DFki

Species
Mus musculus
Symbol
Tg(Plp1-Ncre)DFki
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • PCND
  • PLP-NCre
Description
The coding sequence for improved cre recombinase was split into two complementary halves. For this transgene construct, the n-terminal half of the cre gene encoding for amino acids 19-59 was fused on its 5' end to an element encoding the coiled-coil leucine zipper domain of the yeast transcription factor GCN4. A Flag tag was also included on the 5' end of the fused construct. This construct was placed under control of the murine Plp1 promoter to drive expression in oligodendrocytes. When this transgene is co-expressed with a transgene that expresses the c-terminal half of icre fused to a leucine zipper domain, the leucine zippers force dimerization resulting in a functional cre recombinase. This line is one of three lines created (A,C,D).
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
None
Knock-down Targets
None
Regulatory Regions
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
    Disease Qualifier
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