Version: 8.0.0
Date: Tue Jan 28 2025
Gt(ROSA)26Sortm1(Tcfe2a/Tal1)Xhsu
MGI:3833549
Allele of Gt(ROSA)26Sor
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Gt(ROSA)26Sortm1(Tcfe2a/Tal1)Xhsu

Species
Mus musculus
Symbol
Gt(ROSA)26Sortm1(Tcfe2a/Tal1)Xhsu
Category
allele
Allele of gene
Gt(ROSA)26Sor
Transgenic Constructs
None
Synonyms
  • ET2
Description
A selection marker and a transcriptional stop cassette were flanked by loxP sites and placed upstream of a chimeric gene. This chimeric gene encodes the transactivation domains of Tcfe2a (E47) and the bHLH domain of Tal1 (SCL). An IRES-GFP cassette was placed downstream of the chimeric gene and the whole construct (loxP-neo-STOP-loxp- Tcfe2a/Tal1-IRES-GFP) was knocked into the locus. Upon expression of cre recombinase, the chimeric protein and GFP will be expressed, with the chimeric protein predicted to have a dominant negative effect on members of the Id and Tal protein family due to its strong affinity for E transcription factors.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
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