Allele/Variant

Tg(Myh6-Pln)416Egk

Species
Mus musculus
Symbol
Tg(Myh6-Pln)416Egk
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • Tg(Pln)416Egk
  • TgPLNwt
Description
The transgene comprises a wild-type mouse phospholamban cDNA that contains 13 bp of 5' untranslated sequence, the entire coding region and 434 bp of 3' untranslated sequence, including the first endogenous polyadenylation site, followed by an SV40 polyadenylation signal and driven by the 5.5 kb cardiac-specific alpha myosin heavy chain (myosin, heavy polypeptide 6, cardiac muscle, alpha) promoter. Northern blot analysis revealed cardiac expression of the 1.0 kb transcript from the transgene, and quantitative immunoblot analysis demonstrated overexpression of phospholamban protein in the hearts of transgenic mice.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations