Ttr^tm2(TTR)Kymm

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Species

Mus musculus

Symbol

Ttr^tm2(TTR)Kymm

Category

allele

Allele of gene

Ttr

Transgenic Constructs

Synonyms

• I(-)P(+)
• Ttr^hTTRVal30

Show All 3

Description

ES cells containing the Ttr^tm1Kymm null allele that serves as acceptor in recombination mediated cassette exchange were electroporated with a replacement vector and a cre recombinase expression vector. The replacement vector consisted of a wild-type human TTR cDNA and a FRT-flanked puromycin resistance gene flanked by a lox66 and a loxP site. Northern blot analysis indicated gene expression in the brain, liver and eye of homozygote mice was similar to endogenous expression in wild-type mice. Human but not mouse TTR protein was detected in the liver and serum of homozygote mice in immunoblot assays.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations