Ttr^{tm3(TTR*)Kymm}

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Species

Mus musculus

Symbol

Ttr^{tm3(TTR*)Kymm}

Category

allele

Allele of gene

Ttr

Transgenic Constructs

Synonyms

• Ttr^hTTRMet30
• TTR^MET30

Description

ES cells containing the Ttr^tm1Kymm null allele that serves as acceptor in recombination mediated cassette exchange were electroporated with a replacement vector and a cre recombinase expression vector. The replacement vector consisted of a variant human TTR cDNA and a FRT-flanked puromycin resistance gene flanked by a lox66 and a loxP site. The variant sequence encodes a Methionine at position 30 instead of a Valine (V30M). Human but not mouse TTR protein was detected in the liver and serum of homozygote mice by immunoblot assays.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations