Version: 8.0.0
Date: Tue Jan 28 2025
Glis3tm1Amj
MGI:3848053
Allele of Glis3
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Glis3tm1Amj

Species
Mus musculus
Symbol
Glis3tm1Amj
Category
allele
Allele of gene
Glis3
Transgenic Constructs
None
Synonyms
  • Glis3deltaZF5
  • Glis3zf
Description
Exon 4, which contains the sequence coding for zinc finger 5, and parts of intron 3 and 4 were replaced with a neo cassette. Deletion of zinc finger 5 (ZF5) is predicted to disrupt DNA binding ablity and transcriptional activity of the gene. The inability of the protein produced from this allele to activate transcription of a luciferase reporter with a Glis-binding site was confirmed by cellular assay.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
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