Angptl4^tm2Lex

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Species

Mus musculus

Symbol

Angptl4^tm2Lex

Category

allele

Allele of gene

Angptl4

Transgenic Constructs

None

Synonyms

• Angptl4^E40K
• Angptl4^K

Description

The codon encoding the glutamic acid at postion 40 was mutated by a G-to-A transition to instead code for lysine (E40K). A floxed neomycin cassette was included for targeting purposes and was subsequently removed by cre recombinase expression in ES cells. Mutant gene expression in homozygote liver and kidney was similar to endogenous levels as determined by RT-PCR analysis.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations