Allele/Variant

Tg(Myh6-Mapk8*,Myh6-Mapk9*)22.4Jmol

Species
Mus musculus
Symbol
Tg(Myh6-Mapk8*,Myh6-Mapk9*)22.4Jmol
Category
allele
Allele of gene
None
Transgenic Constructs
None
Synonyms
  • dnJNK1/2
  • JNK1/2dn
Description
Dominant negative JNK1 (Mapk8) and JNK2 (Mapk9) cDNAs in which the dual phosphorylation motif TPY was changed to APF were each fused to a 5.5 kb cardiac specific alpha myosin heavy chain promoter. The constructs were mixed and coinjected into FVB/N oocytes. Three independent lines including 22.4 which was chosen as a representative, and 6.1 were found to coexpress equal amounts of each dominant negative protein.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations