Allele/Variant

Letm1Gt(CC0204)Wtsi

Species
Mus musculus
Symbol
Letm1Gt(CC0204)Wtsi
Category
allele
Allele of gene
Letm1
Transgenic Constructs
None
Synonyms
  • Letm1-
Description
The exogenous gene-trap vector sequence, containing an in-frame splice acceptor site followed by coding sequence for a beta-galactosidase/neomycin (beta-Geo) fusion protein, was inserted into the intron following exon 3 (CC0204). The insertion of a trapping vector after exon 3 creates fusion transcripts and premature stop codons, thus preventing the synthesis of full-length mRNA. Full-length mRNA levels are reduced by 50% in heterozygous mutant mice.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
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