Version: 8.0.0
Date: Tue Jan 28 2025
Akap13Gt(CSJ306)Byg
MGI:3880669
Allele of Akap13
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Akap13Gt(CSJ306)Byg

Species
Mus musculus
Symbol
Akap13Gt(CSJ306)Byg
Category
allele
Allele of gene
Akap13
Transgenic Constructs
None
Synonyms
  • deltaGEF
Description
The beta-geo gene trap was inserted into intron 23. This mutation creates a fusion of all three isoforms that disrupts the Rho-guanine nucleotide exchange factor (GEF) and protein kinase D (PKD) binding domains. Quantitative PCR analysis of neonatal heart and lung RNA revealed that expression of the E37-38 exon-exon junction is reduced in heterozygous and completely eliminated in homozygous mutant mice, while expression of the E4-5 exon-exon junction remains unaffected.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
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