Allele/Variant

Uggt1Gt(RST539)Byg

Species
Mus musculus
Symbol
Uggt1Gt(RST539)Byg
Category
allele
Allele of gene
Uggt1
Transgenic Constructs
None
Synonyms
  • ugt1-
Description
The pGT0TMpfs gene trap, containing CD4 transmembrane domain/beta-galactosidase, neomycin phosphotransferase reporter fusion protein (beta-geo), inserted in intron 13. This truncates the coding region of the gene before exon 14 at codon 459 (versus 1551 wild-type). The catalytic domain is encoded by exons 34-41 so this yields a null allele. Immunoblots confirm that no peptide is produced from this allele.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Phenotype
Annotation details
Source
References
abnormal endoplasmic reticulum physiologyMGI
lethality throughout fetal growth and development, incomplete penetranceMGI
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Disease Associations