Brip1^{Gt(RRI409)Byg}

---

Species

Mus musculus

Symbol

Brip1^{Gt(RRI409)Byg}

Category

allele

Allele of gene

Brip1

Transgenic Constructs

None

Synonyms

• Fancj^-
• Fancj^GT

Description

The gene trap cassette inserted into intron 5 of the gene. This is predicted to result in a disruption of the majority of the sequence that encodes the helicase domain, loss of the BRCA1 interaction domain, and partial loss of the nuclear localization sequence. The MLH1 interaction domain, encoded within exon 5, remains intact. Western blot analysis confirmed loss of the encoded protein in MEF and testis lysates from homozygous mutant mice.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations