Appl1^{Gt(RRS819)Byg}

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Species

Mus musculus

Symbol

Appl1^{Gt(RRS819)Byg}

Category

allele

Allele of gene

Appl1

Transgenic Constructs

None

Synonyms

None

Description

The gene trap vector, pGTxf, which contains a splice acceptor-beta geo cassette-polyadenylation sequence, was inserted between exon 7 and exon 8. The insertion results in the disruption of the gene transcription and expression. Western blot analysis confirmed absence of protein expression in liver, fat, and skeletal muscle tissue homogenates from homozygous mutant mice.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations