Allele/Variant

Adam17tm1.2Bbl

Species
Mus musculus
Symbol
Adam17tm1.2Bbl
Category
allele
Allele of gene
Adam17
Transgenic Constructs
None
Synonyms
None
Description
A targeting vector was designed to insert a loxP site and frt-flanked PGK-neo cassette upstream of exon 2, and a second loxP site downstream of exon 2 of the targeted gene. The resulting mutant mice were then bred to mice expressing Flp recombinase to remove the frt-flanked neo cassette.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal bone marrow cavity morphologyMGI
abnormal bone remodelingMGI
abnormal circulating chemokine levelMGI
abnormal epidermal layer morphologyMGI
abnormal hair growthMGI
abnormal long bone epiphyseal plate proliferative zoneMGI
abnormal long bone hypertrophic chondrocyte zoneMGI
abnormal skin conditionMGI
abnormal skin morphologyMGI
abnormal spleen morphologyMGI
Showing 1 - 10 of 46 rows
per page

Disease Associations

Association
Disease Qualifier
Disease
Annotation details
Evidence
Source
References
is implicated inatopic dermatitis
  • TAS
Showing 1 - 1 of 1 rows
per page