Allele/Variant

Tg(Vav1-NUP98/HOXD13)C1Apla

Species
Mus musculus
Symbol
Tg(Vav1-NUP98/HOXD13)C1Apla
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • NHD13 tg
Description
A transgenic construct containing cDNA of the amino-terminal region of the human nucleoporin 98kDa (NUP98) fused to the homeodomain of the human homeobox D13 (HOXD13) under the control of the 3' and 5' mouse vav 1 oncogene (Vav1) regulatory elements and SV40 polyadenylation site sequence was injected into fertilized FVB/N mouse eggs. Five founders were obtained but only 1 line, C1, transmitted the transgene. Founder line C1 was subsequently established. Expression is detected in hematopoietic tissues, such as thymus, spleen, and bone marrow, but not in nonhematopoietic tissues like brain, kidney, and liver.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations