Allele/Variant

Tg(Prnp-RTN3)2Yanr

Species

Mus musculus

Symbol

Tg(Prnp-RTN3)2Yanr

Category

allele

Allele of gene

None

Transgenic Constructs

Synonyms

hRTN3
RTN3-Tg2

Description

The hRTN3 transgene was designed with a C-terminally myc-tagged human reticulon 3 (RTN3) cDNA inserted between exon 2 and exon 3 of mouse prion protein (PrP or Prnp) gene at two unique XhoI sites in the Mo-Prp.Xho plasmid vector. This transgene was microinjected into the male pronuclei of fertilized FVB/N oocytes. Mice from founder line 2 (RTN3-Tg2) were bred with C57BL/6J mice to establish the colony. Line 2 expressed 1-2-fold higher levels of reticulon 3 compared to wild-type.

Additional Information

Literature

Transgenic Constructs

This allele contains 1 transgenic construct

Symbol

Expressed Components

RTN3 (Hsa)

Knock-down Targets

None

Regulatory Regions

None

All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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Disease Associations

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