Allele/Variant

Tg(Camk2a-HRAS*G12V)1Sva

Species
Mus musculus
Symbol
Tg(Camk2a-HRAS*G12V)1Sva
Category
allele
Allele of gene
None
Transgenic Constructs
None
Synonyms
  • H-rasG12V
  • Tg(Camk2a-HRAS1*G12V)1Sva
Description
The promoter was used to drive expression in postmitotic neurons of the HA-tagged human cDNA that contains nucleotide substitutions that result in the amino acid substitution of valine for glycine at position 12 (G12V). This mutation produces a constitutively active product.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal CNS synaptic transmissionMGI
abnormal excitatory postsynaptic potentialMGI
abnormal miniature excitatory postsynaptic currentsMGI
abnormal spatial learningMGI
abnormal synaptic vesicle clusteringMGI
enhanced contextual conditioning behaviorMGI
enhanced long-term potentiationMGI
enhanced paired-pulse facilitationMGI
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Disease Associations