Allele/Variant

Krt2tm1a(KOMP)Wtsi

Species
Mus musculus
Symbol
Krt2tm1a(KOMP)Wtsi
Category
allele
Allele of gene
Krt2
Transgenic Constructs
None
Synonyms
  • Krt2-
Description
The L1L2_Bact_P cassette was inserted at position 101721229 of Chromosome 15 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 101723984. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal corneocyte morphologyMGI
abnormal epidermis suprabasal layer morphologyMGI
abnormal keratinocyte differentiationMGI
acanthosisMGI
epidermal hyperplasiaMGI
hypergranulosisMGI
hyperkeratosisMGI
impaired skin barrier functionMGI
increased ear pigmentationMGI
increased keratinocyte proliferationMGI
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Disease Associations

No data available