Allele/Variant

Tulp4tm1a(KOMP)Wtsi

Species
Mus musculus
Symbol
Tulp4tm1a(KOMP)Wtsi
Category
allele
Allele of gene
Tulp4
Transgenic Constructs
None
Synonyms
  • Tulp4-
Description
The L1L2_Bact_P cassette was inserted at position 6256719 of Chromosome 17 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 6257585. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal artery morphologyMGI
abnormal cardiovascular system morphologyMGI
abnormal external carotid artery originMGI
abnormal hepatic portal vein connectionMGI
abnormal hepatic vein connectionMGI
abnormal infrahyoid muscle morphologyMGI
abnormal liver vasculature morphologyMGI
abnormal rib developmentMGI
abnormal stapedial artery morphologyMGI
abnormal sternum morphologyMGI
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Disease Associations

No data available