Nkx3-1^{tm4(cre/ERT2)Mms}

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Species

Mus musculus

Symbol

Nkx3-1^{tm4(cre/ERT2)Mms}

Category

allele

Allele of gene

Nkx3-1

Transgenic Constructs

Synonyms

• Nkx3-1^CreERT2

Description

A cre/ERT2-polyA sequence was inserted at the translation start site of the Nkx3-1 gene, thus generating a null allele. The targeting vector also contained a self-excising ACE-cre/PolII-neo selection cassette for positive selection and a PGK-tk (thymidine kinase) cassette for negative selection. The vector was transfected into TC-1 ES cells which were used to generate chimeras. Excision of the selection cassette occurred by passage through the male germline.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations