Version: 8.0.0Date: Tue Jan 28 2025
Allele/Variant
Tg(Slc6a4-cre/ERT2)EZ8Gsat
- Species
- Mus musculus
- Symbol
- Tg(Slc6a4-cre/ERT2)EZ8Gsat
- Category
- allele
- Allele of gene
- None
- Transgenic Constructs
- Synonyms
- Founder Line EZ8
- Tg(Slc6a4-cre/Esr1)8Gsat
- Description
- This transgene contains the coding sequence for the Cre-ERT2 fusion protein, followed by a polyadenylation signal, inserted into a mouse genomic artificial chromosome (BAC) at the ATG transcription initiation codon of the solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 gene so that expression of the tamoxifen-activated recombinase is driven by the regulatory sequences of the mouse gene. ERT2 is a triply mutated (G400V, M543A, L544A) human estrogen receptor ligand-binding domain that renders the fusion protein highly sensitive to activation by 4-hydroxytamoxifen, but unresponsive to the receptor's native ligands.
- Additional Information
- Literature
Transgenic Constructs
This allele contains 1 transgenic construct- Symbol
- Expressed Components
- None
- Knock-down Targets
- None
- Regulatory Regions