Allele/Variant

Tg(tetO-HDAC5*)1Eno

Species
Mus musculus
Symbol
Tg(tetO-HDAC5*)1Eno
Category
allele
Allele of gene
None
Transgenic Constructs
None
Synonyms
  • HDAC5(S/A)
Description
This transgene consists of a FLAG-tagged version of human HDAC5 expressed from a tetracycline responsive promoter. In addition serine-to-alanine mutations, at residues 259 and 498, were created to prevent the export of the protein to the cytosol. This transgene acts as a dominant-negative regulator of myocyte enhancer factor-2 signaling.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
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