Allele/Variant

Brca1tm5.1Cxd

Species
Mus musculus
Symbol
Brca1tm5.1Cxd
Category
allele
Allele of gene
Brca1
Transgenic Constructs
None
Synonyms
  • Brca1S1152A
Description
A serine to alanine substitution at amino acid 1152 (S1152A) was introduced into exon 11 and a floxed neo cassette was inserted upstream of exon 11 via homologous recombination. Mating with mice expressing cre recombinase in the germ line excised the floxed neo. This allele results in a mutation of the ataxia telangiectasia mutated homolog (ATM) phosphorylation site. Western blot analysis indicated that mutant protein was expressed at levels similar to those of wild type.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations