Version: 8.0.0
Date: Tue Jan 28 2025
Sox17tm2.1(icre)Heli
MGI:4418897
Allele of Sox17
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Sox17tm2.1(icre)Heli

Species
Mus musculus
Symbol
Sox17tm2.1(icre)Heli
Category
allele
Allele of gene
Sox17
Transgenic Constructs
Synonyms
  • Sox17- 2Aicre
  • Sox17-2A-iCre
Description
The Sox17 translational stop codon in exon 5 was replaced by a T2A (Thosea asigna virus, TaV) self-cleaving peptide followed by the improved Cre (iCre) for the efficient and equimolar translation of Sox17 and icre. Sox17 and icre are postranslationally cleaved by a 2A-mediated ribosome-skipping mechanism. The FRT-flanked neo selection cassette was subsequently deleted in the germline by FLP-mediated recombination.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
None
Knock-down Targets
None
Regulatory Regions
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
    References
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