Allele/Variant

Tg(Notch3*R169C)88Bbb

Species
Mus musculus
Symbol
Tg(Notch3*R169C)88Bbb
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • TgNotch3R169C
Description
The transgene contains a modified rat BAC RPCI31.78K09 with the rat Notch3 gene carrying the CADASIL-associated mutation R169C. Two lines were created (88 and 92). Line 88 exhibit a 4-fold increase in expression and was selected as the representative line.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations