Fgf8^tm1.1Jyhl

---

Species

Mus musculus

Symbol

Fgf8^tm1.1Jyhl

Category

allele

Allele of gene

Fgf8

Transgenic Constructs

None

Synonyms

• Fgf8^deltab

Description

The intron-exon junction sequence of exon 1D, taaagGTA was changed to catatGTA, abolishing the 5' alternative splice acceptor, while the downstream alternative splice acceptor in exon 1D remained intact. A neo cassette flanked with two loxP sites was placed 400 bp downstream of exon 1D, which was excised later by Cre mediated recombination. RT-PCR analyses revealed that Fgf8b and three minor b-type splice variants were absent in E7.5 mutant embryos.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations