Allele/Variant

Fgf8tm1Jyhl

Species
Mus musculus
Symbol
Fgf8tm1Jyhl
Category
allele
Allele of gene
Fgf8
Transgenic Constructs
None
Synonyms
  • Fgf8deltab-neo
Description
The intron-exon junction sequence of exon 1D, taaagGTA was changed to catatGTA, abolishing the 5' alternative splice acceptor, while the downstream alternative splice acceptor in exon 1D remained intact. A neo cassette flanked with two loxP sites was placed 400 bp downstream of exon 1D. RT-PCR analyses revealed that Fgf8b and three minor b-type splice variants were absent in E7.5 mutant embryos. The insertion of neo produced an additional transcript resulted from a cryptic splice donor and acceptor in the neo gene and in the intronic region 360 bp downstream to the neo gene.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
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