Allele/Variant

Ext1tm1.2Vcs

Species
Mus musculus
Symbol
Ext1tm1.2Vcs
Category
allele
Allele of gene
Ext1
Transgenic Constructs
None
Synonyms
  • Ext1e2flinv
  • Ext1tm1.2Kjns
Description
An inverted loxP site was introduced upstream to exon 2 in a genomic fragment containing the Ext1 gene. The fragment was then subcloned into a vector upstream of the forward-facing loxP-flanked neomycin resistance (Neo) cassette. The linearized targeting vector was electroporated into R1 ES cells. Homozygous Ext1tm1Kjns mice were crossed to Prxx1-cre transgenic mice that express cre in the germline. This results in two consequences, either excision of neo only (tm1.1) or neo-excision and exon 2 inversion (tm1.2). Homozygous exon2-inverted animals display embryonic lethality.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
No records match query. Try removing filters.
Showing 0 - 0 of 0 rows
per page

    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
    References
    No records match query. Try removing filters.
    Showing 0 - 0 of 0 rows
    per page