Ext1^tm1.1Vcs

---

Species

Mus musculus

Symbol

Ext1^tm1.1Vcs

Category

allele

Allele of gene

Ext1

Transgenic Constructs

None

Synonyms

• Ext1^e2fl
• Ext1^tm1.1Kjns

Description

An inverted loxP site was introduced upstream to exon 2 in a genomic framgment containing the Ext1 gene. The fragment was then subcloned into a vector upstream of the forward-facing loxP-flanked neomycin resistance (Neo) cassette. The linearized targeting vector was electroporated into R1 ES cells. Homozygous Ext1^tm1Kjns mice were crossed to Prxx1-cre transgenic mice that express cre in the germline. In some of the offspring, excision of the neo cassette only is the genetic consequence, leaving exon 2 flanked by inverted loxP sites. Homozygous animals are viable and fertile.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations