Version: 8.0.0
Date: Tue Jan 28 2025
Rettm2(cre/ERT2)Ddg
MGI:4437245
Allele of Ret
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Rettm2(cre/ERT2)Ddg

Species
Mus musculus
Symbol
Rettm2(cre/ERT2)Ddg
Category
allele
Allele of gene
Ret
Transgenic Constructs
Synonyms
  • Ret-CreERT2
  • RetCreER
Description
The first exon of the Ret gene was targeted for homologous recombination. A sequence encoding inducible cre/ERT2, followed by a loxP-flanked AC-Cre Tn5-neo self-excising cassette, was targeted to exon 1 of Ret in ES cells. Following excision of the floxed neo cassette, a line of knockin mice expressing cre/ERT2 was generated. Spatial and temporal expression patterns of the inducible cre recapitulated Ret expression.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
None
Knock-down Targets
None
Regulatory Regions
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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