Allele/Variant

Tg(Lrrk2)6Yue

Species

Mus musculus

Symbol

Tg(Lrrk2)6Yue

Category

allele

Allele of gene

None

Transgenic Constructs

Synonyms

FLAG-LRRK2-WT
LRRK2-WT^OE

Description

Bacterial artificial chromosome (BAC) library (CHORI) was used to obtain a 240 kb BAC (#RP23-312I9) containing the entire mouse Lrrk2 (leucine-rich repeat kinase 2) gene. This BAC contains a FLAG-tag downstream from the start codon. Founder line 6 was established with expression in cerebral cortex, striatum, substantia nigra, internal capsule, and hippocampus at an approximately 6-8 fold greater level than endogenous mouse Lrrk2.

Additional Information

Literature

Transgenic Constructs

This allele contains 1 transgenic construct

Symbol

Expressed Components

Lrrk2 (Mmu)

Knock-down Targets

None

Regulatory Regions

None

All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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Disease Associations

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