Version: 8.0.0Date: Tue Jan 28 2025
Allele/Variant
Tg(Lrrk2*G2019S)2Yue
- Species
- Mus musculus
- Symbol
- Tg(Lrrk2*G2019S)2Yue
- Category
- allele
- Allele of gene
- None
- Transgenic Constructs
- Synonyms
- FLAG-LRRK2-G2019S
- LRRK2-G2019SOE
- Description
- A bacterial artificial chromosome (BAC) (#RP23-312I9) containing the entire mouse Lrrk2 (leucine-rich repeat kinase 2) gene was modified by targeted mutation of the Lrrk2 locus to harbor the Lrrk2-G2019S mutation associated with autosomal dominant, late-onset Parkinson's disease originally identified in Spanish families originating from the Basque region. This modified 240 kb BAC contains a FLAG-tag downstream from the start codon. Line 2 was established with expression in cerebral cortex, striatum, substantia nigra, internal capsule, and hippocampus at an approximately 6-8 fold greater level than endogenous mouse Lrrk2.
- Additional Information
- Literature
Transgenic Constructs
This allele contains 1 transgenic construct- Symbol
- Expressed Components
- Knock-down Targets
- None
- Regulatory Regions
- None