Allele/Variant

Tg(ACTB-APP*V717F)1Colm

Species
Mus musculus
Symbol
Tg(ACTB-APP*V717F)1Colm
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • APPC100.V717F
  • Tg C100.V717F
Description
The human promoter was used to drive ubiquitous expression of the C-terminal portion of human APP (C100) with an amino acid substitution of phenyalanine for valine at position 717 (V717F), also known as the London mutation. One line was created (no line number given) with 40 to 50 copies of the transgene.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations