Allele/Variant

Tg(Thy1-APPDutch)#Jckr

Species
Mus musculus
Symbol
Tg(Thy1-APPDutch)#Jckr
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
None
Description
A human APP751 cDNA with a mutation in the codon for amino acid residue 693 causing a glutamic acid to glutamine change (E693Q) was place under the control of the murine Thy1.2 minigene. Five positive founder mice were identified. This record is for combined data from the two highest expressing lines, lines 23 and 33. Expression is five times higher than for endogenous APP.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
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