Version: 8.0.0
Date: Tue Jan 28 2025
Tg(Eno2-MFN2*R94Q)L51Ugfm
MGI:4440895Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Tg(Eno2-MFN2*R94Q)L51Ugfm

Species
Mus musculus
Symbol
Tg(Eno2-MFN2*R94Q)L51Ugfm
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • hMFN2R94QL51
  • MitoCharc1
Description
The MitoCharc1 transgene was designed with the human Mitofusin 2 (MNF2) gene driven by a rat enolase (Eno2) promoter. Amino acid 94 of MNF2 was mutated from an Arginine (R) to a Glutamine (Q) to mimic the most commonly mutated residue in Charcot-Marie-Tooth disease type 2A (CMT2A). Line L51 was established.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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