Version: 8.0.0
Date: Tue Jan 28 2025
Tg(CAG-Bgeo,-tsA58T)T26Ichi
MGI:4442215Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Tg(CAG-Bgeo,-tsA58T)T26Ichi

Species
Mus musculus
Symbol
Tg(CAG-Bgeo,-tsA58T)T26Ichi
Category
allele
Allele of gene
None
Transgenic Constructs
None
Synonyms
  • CAG-Betageo-TsA58T tg
  • LBSL-tsTAg
Description
The transgene construct has a loxP-flanked Beta-geo gene driven by the CAG promoter, followed by the SV40 tsA58 large T antigen (cDNA for the SV40 TAg and the 3' portion of tsA58T antigen sequence with the A438V mutation.) In the absence of cre-mediated recombination, Beta-geo is expressed and detected by X-gal staining. Removal of the loxP-flanked Beta-geo results in expression of the tsA58T antigen, leading to temperature-dependent cell-type independent cell proliferation,
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
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    Annotation details
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