Allele/Variant

Acacbtm1.2Lowl

Species
Mus musculus
Symbol
Acacbtm1.2Lowl
Category
allele
Allele of gene
Acacb
Transgenic Constructs
None
Synonyms
  • Acc2KO
Description
LoxP sites were positioned upstream of the preceding exon and downstream of the biotin binding domain exon using an Frt flanked kanamycin resistance cassette. The Frt-flanked selection cassette was removed by Flpe recombinase-mediated recombination. These two exons were deleted by Cre-mediated recombination, which introduces a frameshift and nonsense mutation after Asp865 in any translated protein. Immunoblotting showed no truncated protein expression in muscle lysates from homozygous mice.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations